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Recombinant Human TGF-beta 1

 Recombinant Human TGF-beta 1产品说明(Description)

Recombinant Human Transforming Growth Factor beta 1 is produced by our Mammalian expression system and the target gene encoding Ala279-Ser390 is expressed. 

Accession #: P01137

Known as: Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB


制剂(Formulation)

Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mMNacl, pH2.5.


质量控制(Quality Control) 

Purity:            Greater than 95% as determined by reducing SDS-PAGE.    

Endotoxin:     Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

 

Bioactivity:   Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells.

                        The ED50 for this effect is 0.04-0.2 ng/ml. 

                        

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复溶(Reconstitution)

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in distilled water
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.    


保存(Storage)

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.

Reconstituted protein solution can be stored at 4-7°C for 2-7 days.

Aliquots of reconstituted samples are stable at < -20°C for 3 months.     


背景(Background)

Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.


电泳(SDS-PAGE)


参考文献(Reference)

KrasG12D mutation contributes to regulatory T cell conversion through activation of the MEK/ERK pathway in pancreatic cancer[J]. He Cheng. et al. Cancer Letters. 2019.

The role and molecular mechanism of Trop2 induced epithelial‐mesenchymal transition through mediated β‐catenin in gastric cancer[J]. Wei Zhao. et al. Cancer Medicine. 2019.

Sialylation of vasorin by ST3Gal1 facilitates TGF‐β1 mediated tumor angiogenesis and progression[J]. Hui Ling Yeo. et al. International Journal of Cancer. 2018.

TGF-β1 resulting in differential microRNA expression in bovine granulosa cells[J]. YefenXu.et alGene. 2018.

P16 INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency[J]. Jianliang Jin. et al. Scientific Reports. 2017.

Human mesenchymal stem cells cultured on silk hydrogels with variable stiffness and growth factor differentiate into mature smooth muscle cell phenotype[J]. Floren M. et al. Acta biomaterialia. 2016.

High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling[J]. Zhao Y. et al. Nature communications. 2015.

Engineering an “infectious” Treg biomimetic through chemoselective tethering of TGF-β1 to PEG brush surfaces[J]. E.Y. Yang. et al. Biomaterials. 2015.


 

 

 

 

FOR RESEARCH USE ONLY

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